Pictograms:
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Signal Word: | Danger |
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Hazard Statements: | H301, H310, H315, H319, H335 |
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Precautionary Statements: | P280, P301 + P312, P305 + P351 + P338 |
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UN#: | UN2811 |
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Packing Group: | II |
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Hazard Class: | 6.1
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Flash Point: | 124° |
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RTECS: | US9230000 |
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SDS: | See MSDS
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Limited Quantities: | 100ml (liquid) or 0.5 Kg (solid) |
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Excepted Quantities: | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) |
DMAP is a useful nucleophilic catalyst for a variety of reactions such as esterifications with anhydrides4, the Baylis-Hillman reaction5, hydrosilylations, tritylation, the Steglich rearrangement and the Staudinger synthesis of β-lactams. Chiral DMAP analogues are used in kinetic resolution experiments of mainly secondary alcohols and Evans auxilary type amides. 1,2 DMAP is also used as a coupling agent for the synthesis of peptide and an efficient ligand for the Heck reaction in aqueous media 3.
Reference - Höfle, G., Steglich, W., Vorbrüggen, H.. Angew. Chem. Int. Ed. Engl. 1978, 17, 569.
- Ryan P. Wurz . Chem. Rev. 2007, 107, 5570.
- D. V. Evdokimov, N. A. Bumagin. Russ. Chem. Bull. 2007, 56, 1093.
- Wilson, S.R.; Augelli, C.E. Org. Synth. 1990, 68, 210.
- Rezgui, F.; El Gaied, M. M. Tetrahedron Lett. 1998, 39, 5965.
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