Also called Heavy water. Widely applied in nuclear magnetic resonance, Fourier transform spectroscopy, neutron moderator, neutrino detector, metabolic rate testing in physiology/biology and organic chemistry. Used to prepare highly deuterated hydroxybenzoic acids,1 to deuterate N-benzyl-containing heterocyclic compounds using palladium/carbon-ethylenediamine complexes,2 to prepare deuterated compounds by substitution of carboxyl groups of carboxylic acids with deuterium by photochemical decarboxylation,3 to produce deuterated imidazole derivatives,4 and reduce enones into α,β-dideuterioketones by palladium catalysis.5 Also employed as a deuterium source for catalytic (transfer) deuterogenation,6 and isotopically labeling amino acid derivatives and heterocyclic compounds.7,8
Reference
1. Org. Chem. 2011, 8, 332.
2. JP 2011016745 A 20110127, 2011.
3. Chem. Comm. 2010, 46, 6177.
4. JP 2009242343 A 20091022, 2009.
5. Chem. Comm. 2007, 1819.
6. Dalton Trans. 2009, 6286.
7. Synlett 2008, 402.
8. Tetrahedron 2006, 62, 10954.