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106408

106408-450ml



Capping A, 10% Acetic Anhydride in THF (THF / Acetic Anhydride, V/V = 90:10, emp Biotech 450mL, 28-400 thread, 2.5L, GL45 thread


CAS Number: 108-24-7
   
Molecular Formula: C4H6O3
   
Molecular Weight: 102.09
   
MDL Number:


 Item #PriceQuantityAdd to Cart 
106408-450ml
Regular Price: $60.00
Your Discounted Price: $0.00
In Stock USA
106408-2.5L
Regular Price: $158.00
Your Discounted Price: $0.00
In Stock USA



 
Pictograms:
Signal Word:Danger
Hazard Statements:H225, H302, H315, H318, H331, H335, H336, H351
Precautionary Statements:P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301 + P312, P303 + P361 + P353, P304 + P340, P305 + P351 + P338, P308 + P313, P310, P332 + P313, P362, P370 + P378, P403 + P233, P403 + P235, P405, P501
UN#:UN2056
Packing Group:II
Hazard Class:3
Flash Point:-17°
SDS: See MSDS
 
Limited Quantities:1.0 L (0.3 gallon) (liquid)
Excepted Quantities:Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

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For each synthesis cycle, up to 1 to 2 % of free 5'-hydroxy groups remain after the phosphoramidite coupling step has been completed. By running a subsequent "Capping" step using an anhydride, these free hydroxyl groups are converted to acetates and are hindered from further chain elongation and formation of long oligonucleotides with incorrect sequences. For optimal acetylation, a solution of acetic anhydride in Tetrahydrofuran or acetonitrile (Capping A) will be mixed in situ during reaction with a catalytic acting solution of N-methylimidazole (Capping B). Additives such as pyridine and lutidine function as mild bases to enhance the efficiency of the capping reaction.

Product of emp Biotech GmbH
Size bottle:
450 mL, 28-400 thread, emp Biotech part no. NC-0702-M450.0-001
2.5 L with GL45 thread, emp Biotech part no. NC-0702-N002.5-001

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