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024893

024893-1g



DEPBT


CAS Number: 165534-43-0
   
Molecular Formula: C11H14N3O5P
   
Molecular Weight: 299.23
   
MDL Number: MFCD01236967


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024893-1g
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024893-5g
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024893-25g
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024893-100g
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024893-500g
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Purity:99%
Mp:72-75°
 
Pictograms:
Signal Word:Warning
Hazard Statements:H302, H315, H319, H335
Precautionary Statements:P261, P301 + P312, P302 + P352, P304 + P340, P305 + P351 + P338
SDS: See MSDS
 

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An effective coupling reagent for synthesis of linear and cyclic peptides in both solution and solid phase with very little epimerization.1 There is no need to protect the hydroxy group of the amino component (such as tyrosine, serine, and threonine) and the imidazole group in the case of histidine when DEPBT is involved.2 DEPBT has been applied in the syntheses of complex natural products such as ramoplanin A2, ramoplanose aglycon, ustiloxin, and teicoplanin aglycon in high efficiency.2,3,4

  1. Org. Lett. 1999, 1, 91.
  2. Pep. Sci. 2005, 80, 172.
  3. J. Am. Chem. Soc. 2000, 122, 7416.
  4. Pep. Res. 2002, 60, 95.

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