A coupling reagent for peptide and organic synthesis.1,2 Applied in synthesis of leuenkephalin amide on a solid support suspended in aq. 50% EtOH,2 synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]octahydro-1H-indole-2-carboxylic acid derivatives,3 active ester formation and oxazolone formation by reaction with Z-Gly-Ala-OH,4 and formation of Fmoc-L-Ala-L-Phlac-OCH2Ph and Fmoc-D-Ala-L-Phlac-OCH2Ph.5 Also used for fabricating a novel reusable electrochemical immunosensor by immobilizing of 3-aminophenylboronic acid conjugated thiol-mixed monolayer on gold though TNTU as linkage.6
Reference
1. Pept., Proc. Eur. Pept. Symp., 20th, 1989, 37
2. Protein Peptide Lett. 2006, 13, 189.
3. EP 1420030 A2 20040519, 2004.
4. Pept., Proc. Eur. Pept. Symp., 24th, 1996, 455.
5. J. Chem. Soc., Perkin Trans. 2, 1995, 2335.
6. Talanta 2008, 77, 815.