A Coupling agent for the synthesis of peptides in solid phase as well as solution. HONB mediated amide coupling reactions in two-phase solvent mixtures afford peptides in high yields with little racemization. 1 HONB can promote imidazolide couplings2 and can be used for enhancement of peptide coupling mediated by EDC [N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide-HCl] in aqueous media 3.
1. J. Org. Chem. 1995, 60, 3569.
2. Org. Proc. Res. Dev. 2004, 8, 1054.
3. Chem. Lett. 1997, 1, 1