A chloroformate ester. Reagent for introducing Fmoc group. For preparing N-Fmoc amino acids in solid-phase peptide synthesis by reaction with the amine.1,2 Also used to synthesis of Fmoc-Osu by the reaction with the dicyclohexylammonium salt of N-hydroxysuccinimide.3 Reagent for derivatizing amino acids for HPLC amino acid analysis4,5 and for for the pre-column fluorescent derivatization of amino acids.6,7
1. Tetrahedron Lett. 2001, 42, 2587.
2. ARKIVOC 2008 (ii) 243.
3. Int. J. Pept. Protein Res. 1985, 27, 398.
4. J. Chromatogr. B 2007, 860, 42.
5. Chirality 2007, 20, 63.
6. Chromatographia 1997, 46, 245.
7. J. Chromatogr. A 2001, 938, 15.