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Purity: | 99% |
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Bp: | 56-57°/0.5mm |
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Mp: | 23° |
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Density: | 0.950 |
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Refractive Index: | 1.4090 |
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Pictograms:
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Signal Word: | Danger |
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Hazard Statements: | H228.2, H312, H319, H330 |
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Precautionary Statements: | P201, P202, P231 + P232, P233, P235, P240, P241, P242, P243, P260, P280, P284, P301 + P312, P302 + P352, P304 + P340, P305 + P351 + P338, P310, P332 + P313, P337 + P313, P403 + P233, P403 + P235 |
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UN#: | UN2930 |
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Packing Group: | II |
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Flash Point: | 37° |
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RTECS: | HT0230000 |
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SDS: | See MSDS
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Limited Quantities: | 100ml (liquid) or 0.5 Kg (solid) |
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Excepted Quantities: | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) |
A reagent to form t-BOC derivatives with amines.1 Protection of alcohols as Boc derivatives via Lewis acid catalysis.2 Mainly used to introduce t-Boc protecting group in peptide synthesis.3,4,5 Also used as a coupling reagent in synthesis of tert-butyl carbamates by the reaction with carboxylic acids including aromatic and aliphatic acids, and Fmoc-protected amino acids6, synthesis of 6-acetyl-1,2,3,4-tetrahydropyridine from 2-piperidone7 and tert-butoxycarbonylation of indoles8.
1. “Di-t-butyl Dicarbonate” in Encyclopedia of Reagents for Organic Synthesis, 2004. 2. Synlett, 2006, 2104. 3. Synth. Commun. 2007, 37, 4191. 4. Synthesis 2009, 283. 5. Org. Lett. 2006, 8, 3259. 6. Org. Lett. 2005, 7, 4107. 7. J. Org. Chem. 2005, 70, 10872. 8. Synlett 2008, 294.
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